• Why does miR-145 exist? It acts as a Schmitt trigger (a bistable circuit element in electronics). OCT4 represses miR-145, and miR-145 degrades OCT4. When OCT4 drops below a critical threshold, miR-145 spikes, rapidly chewing up any leftover mRNA and preventing the cell from wavering back. could be good to add to the “biological analogs of circuit elements” wiki page or create something with a similar concept