Measuring genomic instability

If you buy into tumor suppression lens on aging, then reducing DNA mutations and epimutations is the priority number one (followed by priority number 2, killing off somatic drifters, and priority number 3, disabling constitutive tumor suppression adaptations)

Let’s say someone comes up to you claiming they have a method to reduce or repair age-driven DNA instability. What experiments could you conduct to check if that method really works?

We’ll look at the methods that are used to validate this narrow task - that genomic instability is actually reduced, and by how much - without getting into the whole speculative