APAF1
What it is. Scaffold that assembles the apoptosome to activate caspase‑9.
Why it matters here. Loss blocks caspase activation and apoptosis.
Notes. Partners: cytochrome c, caspase‑9.
- content(70)
- wiki(65)
- AKT1
- AKT2 (AKT2)
- Antagonistic Pleiotropy Theory
- APAF1
- ARF (p14^ARF)
- ATM
- ATR
- BAK (BAK1)
- BAX
- BCL‑2
- BCL‑XL (BCL2L1)
- beta-catenin (CTNNB1)
- BRAF (BRAF)
- Caspase-3 (CASP3)
- Cellular Senescence
- CTLA-4 (CTLA4)
- CTVT - Canine Transmissible Venereal Tumor
- De-Darwinization
- Death Pact
- Disposable Soma Theory
- E2F1 (E2F1)
- EGF (EGF)
- EGFR (ERBB1)
- FAS (CD95)
- Fibrinogen alpha chain (FGA)
- FOXO3 (FOXO3)
- GAPDH
- Glossary
- HLA-A (HLA-A)
- IGF-1
- IL-10
- IL-6
- IL-8 (CXCL8)
- Insulin
- KRAS (KRAS)
- Lewontin's conditions
- MAP2K1 (MEK1)
- MCL-1
- MDM2
- MMP9 (MMP9)
- MTOR (MTOR)
- MYC
- NFE2L2 (NRF2)
- NOTCH1 (NOTCH1)
- p16^INK4a (CDKN2A)
- p21^CIP1 (CDKN1A)
- p53 (TP53)
- PD-1 (PDCD1)
- PD-L1 (CD274)
- PIK3CA (PIK3CA)
- PRKAA1 (AMPKα1)
- Rb (RB1)
- Selection Shadow Theory
- Self-Fertilization
- SIRT1 (SIRT1)
- Sonic hedgehog (SHH)
- TAZ (WWTR1)
- Telomerase (TERT)
- Telomeres
- TGF-beta 1 (TGFB1)
- TNF (TNF)
- Tumor Suppressor Theory of Aging
- VEGF (VEGFA)
- WNT3A (WNT3A)
- YAP (YAP1)
- post(3)
- apps(2)
- protein(53)
- AKT1
- AKT2 (AKT2)
- APAF1
- ARF (p14^ARF)
- ATM
- ATR
- BAK (BAK1)
- BAX
- BCL‑2
- BCL‑XL (BCL2L1)
- beta-catenin (CTNNB1)
- BRAF (BRAF)
- Caspase-3 (CASP3)
- CTLA-4 (CTLA4)
- E2F1 (E2F1)
- EGF (EGF)
- EGFR (ERBB1)
- FAS (CD95)
- Fibrinogen alpha chain (FGA)
- FOXO3 (FOXO3)
- GAPDH
- HLA-A (HLA-A)
- IGF-1
- IL-10
- IL-6
- IL-8 (CXCL8)
- Insulin
- KRAS (KRAS)
- MAP2K1 (MEK1)
- MCL-1
- MDM2
- MMP9 (MMP9)
- MTOR (MTOR)
- MYC
- NFE2L2 (NRF2)
- NOTCH1 (NOTCH1)
- p16^INK4a (CDKN2A)
- p21^CIP1 (CDKN1A)
- p53 (TP53)
- PD-1 (PDCD1)
- PD-L1 (CD274)
- PIK3CA (PIK3CA)
- PRKAA1 (AMPKα1)
- Rb (RB1)
- SIRT1 (SIRT1)
- Sonic hedgehog (SHH)
- TAZ (WWTR1)
- Telomerase (TERT)
- TGF-beta 1 (TGFB1)
- TNF (TNF)
- VEGF (VEGFA)
- WNT3A (WNT3A)
- YAP (YAP1)
- meta(1)
- untagged(8)
APAF1
APAF1
Molecular→Persona
Mass142 kDa
→Height142 cm
TransmembraneNo
→GenderFemale
Membrane Depth0
→Settingouter space
Classificationtumor_suppressor
→Politicspro-Control
First LetterA
→Skin HueA
RVIS11
→Skin Lightness11%
Tissue Specificity51
→Skin Saturation51%
Disorder19%
→Age19