MDM2
What it is. E3 ubiquitin ligase that targets p53 for degradation.
Why it matters here. Amplification reduces p53 levels and weakens intrinsic policing.
Notes. Type: ubiquitin ligase; Regulator: inhibited by ARF.
What it is. E3 ubiquitin ligase that targets p53 for degradation.
Why it matters here. Amplification reduces p53 levels and weakens intrinsic policing.
Notes. Type: ubiquitin ligase; Regulator: inhibited by ARF.