Novak–Tyson model

The Novak–Tyson model is a mathematical and computational framework that describes the biochemical network regulating the eukaryotic cell cycle, specifically the transitions into and out of mitosis (M-phase). Developed by biochemist Béla Novák and mathematical biologist John J. Tyson in 1993, the model simulates how cells coordinate growth and division. By representing biochemical interactions as a system of non-linear ordinary differential equations, the model tracks the concentrations and activity levels of key regulatory proteins, particularly the M-phase promoting factor (MPF). The initial iteration of the model focused on Xenopus (frog) egg extracts and embryos, and subsequent versions were adapted to model cell division