SIRT1 (SIRT1)
What it is. NAD-dependent deacetylase that modulates transcription factors and repair proteins, coupling cellular state to gene regulation and cleanup pathways.
Why it matters here. Supports stress-responsive programs that keep damaged cells in check and preserves cooperative function; loss of these restraints can ease steps toward malignant autonomy.
Notes. Targets include FOXO, p53, PGC-1α; communicates with mTOR and AMPK through autophagy and metabolic control.