Types of tumor suppressor genes
The types of tumor suppressor genes most commonly distinguished in cancer biology are gatekeeper, caretaker, and landscaper genes. They differ by the control that is lost when a gene is inactivated: direct growth restraint, genome maintenance, or regulation of the surrounding tissue.
Classification
Tumor suppressor genes are grouped by the control that is lost when the gene is inactivated:
- Gatekeepers: restrain the potentially malignant cell itself by limiting division, enforcing cell-cycle arrest, or promoting apoptosis.
- Caretakers: maintain genomeLog in with DiscordSupport BrinedewContinue to read the draft.
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