XIAP

What it is. Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis (PubMed:11257230, PubMed:11257231, PubMed:11447297, PubMed:12121969, PubMed:12620238, PubMed:17560374, PubMed:17967870, PubMed:19473982, PubMed:20154138, PubMed:22103349, PubMed:9230442).

Why it matters here.

Notes. Type: ; Pathways: SMAC, XIAP-regulated apoptotic response, SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes, Activation of caspases through apoptosome-mediated cleavage.