Baker INK-ATTAC experiment
The Baker INK-ATTAC experiment was a pair of transgenic mouse studies, published in 2011 and 2016, that tested whether removing p16^INK4a-expressing senescent cells changes age-related disease. Darren Baker, Jan van Deursen, and colleagues built a transgene, INK-ATTAC, that kills p16-positive cells when the mice receive a dimerizer drug. The 2011 study removed those cells in a progeroid mouse strain and delayed several age-related pathologies. The 2016 study removed naturally accumulating p16-positive cells in normal mice and extended median lifespan. Together they supplied causal evidence that senescent cells contribute to age-related dysfunction.12
Background
Cellular senescence arrests damaged cells and suppresses tumor formation, and
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