FOXO3 (FOXO3)

What it is. Forkhead transcription factor integrating stress signals to adjust repair, cell-cycle arrest, and metabolic programs.

Why it matters here. When freed from AKT-driven inhibition, FOXO3 reinforces cooperative safeguards—reducing the chance that stressed cells drift toward competitive, oncogenic behavior.

Notes. Regulated by AKT phosphorylation and nuclear localization; coordinates with SIRT1 and AMPK.