Showing 140 of 140 entries
StageNoteUpdatedStatus
draftMeasuring somatic mosaicism and genomic instability92d ago
draftMitosis vetoes99d ago
draftWhy would fish cells die when fish dies?113d ago
draftHow come theres 1 smell per neuron169d ago
draftEutely302d ago
draftTypes of scientific explanations71d ago
draftTaxonomy of AI footguns for non-coders289d ago
draftAKT1289d ago
draftFOXO3 (FOXO3)289d ago
draftGAPDH289d ago
draftMTOR (MTOR)289d ago
draftNFE2L2 (NRF2)289d ago
draftPRKAA1 (AMPKα1)289d ago
draftSIRT1 (SIRT1)289d ago
draftWould pharma whistleblower bounties help or hurt the war on aging?30d ago
draftClonal governance37d ago
draftMemes79d ago
draftImmortality has a PR problem86d ago
draftMultipolar traps in multicellularity114d ago
draftDunking on medawar selection shadow128d ago
draftTypes of tumor suppressor genes191d ago
draftResearch Gaps — Cnidarian Longevity & Rejuvenation303d agodraft
draftTrivia84d ago
draftAKT2 (AKT2)301d ago
draftAPAF1301d ago
draftARF (p14^ARF)301d ago
draftATM301d ago
draftATR301d ago
draftBAK (BAK1)301d ago
draftBAX301d ago
draftBCL‑2301d ago
draftBCL‑XL (BCL2L1)301d ago
draftbeta-catenin (CTNNB1)301d ago
draftBRAF (BRAF)301d ago
draftCaspase-3 (CASP3)301d ago
draftCTLA-4 (CTLA4)301d ago
draftE2F1 (E2F1)301d ago
draftEGF (EGF)301d ago
draftEGFR (ERBB1)301d ago
draftFAS (CD95)301d ago
draftFibrinogen alpha chain (FGA)301d ago
draftFlower (Drosophila)301d agodraft
draftHLA-A (HLA-A)301d ago
draftIGF-1301d agodraft
draftIL-10301d agodraft
draftIL-6301d agodraft
draftIL-8 (CXCL8)301d agodraft
draftInsulin301d agodraft
draftKRAS (KRAS)301d ago
draftMAP2K1 (MEK1)301d ago
draftMCL-1301d agodraft
draftMDM2301d agodraft
draftMMP9 (MMP9)301d ago
draftMYC301d agodraft
draftNOTCH1 (NOTCH1)301d ago
draftp16^INK4a (CDKN2A)301d agodraft
draftp21^CIP1 (CDKN1A)301d agodraft
draftp53 (TP53)301d agodraft
draftPD-1 (PDCD1)301d agodraft
draftPD-L1 (CD274)301d agodraft
draftPIK3CA (PIK3CA)301d ago
draftRb (RB1)301d agodraft
draftSonic hedgehog (SHH)301d ago
draftTAZ (WWTR1)301d agodraft
draftTelomerase (TERT)301d agodraft
draftTGF-beta 1 (TGFB1)301d ago
draftTNF (TNF)301d ago
draftVEGF (VEGFA)301d agodraft
draftWNT3A (WNT3A)301d ago
draftYAP (YAP1)301d agodraft
draftDNMT1256d ago
draftJAK2256d ago
draftLMNA256d ago
draftOGG1256d ago
draftQSOX1256d ago
draftUBE3A256d ago
draftXIAP256d ago
draftZEB1256d ago
draftArmitage–Doll model221d ago
draftTomasetti–Vogelstein model221d ago
draftIncentive design for animal lifespan prizes228d ago
draftWhen to not cure aging81d ago
draftVigilance glossary298d ago
draftOne-Hit Cancer312d ago
draftAppendix: Telomere Dynamics, Cancer Suppression, and Evolutionary Insights312d ago
draftAging is a disease312d ago
draftAging research is different from most research312d ago
draftHas lifespan extension research plateaued312d ago
draftLong telomeres extend lifespan312d ago
draftLoyalists, drifters, defectors312d ago
draftMutation accumulation misconception312d ago
draftSo you want to be a transmissible tumor312d ago
draftThe parable of the thermometer312d ago
draftThe Price of Not Being Cancer312d ago
draftTwo types of longevity interventions312d ago
draftVibes are principal components312d ago
draftAtavistic Theory of Cancer312d ago
draftSelf-Fertilization312d ago
draftAntagonistic Pleiotropy Theory312d ago
draftCellular Senescence312d ago
draftCTVT - Canine Transmissible Venereal Tumor312d ago
draftDeath Pact312d ago
draftDefensive Degeneration Theory312d ago
draftDevil Facial Tumor Disease (DFTD)312d ago
draftDisposable Soma Theory312d ago
draftHeLa Cells312d ago
draftImmune Surveillance312d ago
draftHow malignant cells evade host coordination systems312d ago
draftPrincipal-Agent Problem312d ago
draftReplicative Credit312d ago
draftSCANDAL Hypothesis312d ago
draftSelection Shadow Theory312d ago
draftTelomeres312d ago
draftTumor Suppressor Theory of Aging312d ago
draftWeismann Barrier312d ago
draftLewontin's conditions271d ago
draftDe-Darwinization271d ago
draftctvt_cancer_line257d ago
draftPathway macrostates47d ago
draftWhy does DNA Damage Response damage DNA47d ago
draftRepairman's paradox trips up engineers in biology5d ago
draftSubmarine analogy194d ago
draftCriticism of Dwarkesh Podcast - Jacob Kimmel Interview299d ago
draftBiologist learns control theory68d ago
draftWhat is an agent241d ago
draftwhy dont biologists use openreview38d ago
draftTypes of cell senescence45d ago
draftEvolutionary Transitions in Individuality: much more than you wanted to know108d ago
draftLabs10d ago
draftTypes of explanations in biology157d ago
draftWhy would cancer cure Alzheimer's?129d ago
draftThe first sacrifice136d ago
draft10 intuitions on tissue architecture178d ago
draftEvolution Simulation Demo311d ago
draftWhy doesn't liver age faster?52d ago
draftIndeterminate growth286d ago
draftDump note251d ago
draftSomatic Engineering Manifesto223d ago
draftDefensive sabotage is not friendly fire90d ago
draftRepurposed for altruism104d ago
Showing 140 of 140 entries
Measuring somatic mosaicism and genomic instability
NoteMeasuring somatic mosaicism and genomic instability
Mtime"2026-03-18T00:00:00.000Z"
Mitosis vetoes
NoteMitosis vetoes
Mtime"2026-03-11T00:00:00.000Z"
Why would fish cells die when fish dies?
NoteWhy would fish cells die when fish dies?
Mtime"2026-02-25T00:00:00.000Z"
How come theres 1 smell per neuron
NoteHow come theres 1 smell per neuron
Mtime"2025-12-31T00:00:00.000Z"
Eutely
NoteEutely
Mtime"2025-08-20T00:00:00.000Z"
Types of scientific explanations
NoteTypes of scientific explanations
Mtime"2026-04-08T00:00:00.000Z"
Taxonomy of AI footguns for non-coders
NoteTaxonomy of AI footguns for non-coders
Mtime"2025-09-02T00:00:00.000Z"
AKT1
NoteAKT1
Mtime"2025-09-02T00:00:00.000Z"
FOXO3 (FOXO3)
NoteFOXO3 (FOXO3)
Mtime"2025-09-02T00:00:00.000Z"
GAPDH
NoteGAPDH
Mtime"2025-09-02T00:00:00.000Z"
MTOR (MTOR)
NoteMTOR (MTOR)
Mtime"2025-09-02T00:00:00.000Z"
NFE2L2 (NRF2)
NoteNFE2L2 (NRF2)
Mtime"2025-09-02T00:00:00.000Z"
PRKAA1 (AMPKα1)
NotePRKAA1 (AMPKα1)
Mtime"2025-09-02T00:00:00.000Z"
SIRT1 (SIRT1)
NoteSIRT1 (SIRT1)
Mtime"2025-09-02T00:00:00.000Z"
Would pharma whistleblower bounties help or hurt the war on aging?
NoteWould pharma whistleblower bounties help or hurt the war on aging?
Mtime"2026-05-19T00:00:00.000Z"
Clonal governance
NoteClonal governance
Mtime"2026-05-12T00:00:00.000Z"
Memes
NoteMemes
Mtime"2026-03-31T00:00:00.000Z"
Immortality has a PR problem
NoteImmortality has a PR problem
Mtime"2026-03-24T00:00:00.000Z"
Multipolar traps in multicellularity
NoteMultipolar traps in multicellularity
Mtime"2026-02-24T00:00:00.000Z"
Dunking on medawar selection shadow
NoteDunking on medawar selection shadow
Mtime"2026-02-10T00:00:00.000Z"
Types of tumor suppressor genes
NoteTypes of tumor suppressor genes
Mtime"2025-12-09T00:00:00.000Z"
Research Gaps — Cnidarian Longevity & Rejuvenation
NoteResearch Gaps — Cnidarian Longevity & Rejuvenation
Mtime"2025-08-19T00:00:00.000Z"
Trivia
NoteTrivia
Mtime"2026-03-26T00:00:00.000Z"
AKT2 (AKT2)
NoteAKT2 (AKT2)
Mtime"2025-08-21T00:00:00.000Z"
APAF1
NoteAPAF1
Mtime"2025-08-21T00:00:00.000Z"
ARF (p14^ARF)
NoteARF (p14^ARF)
Mtime"2025-08-21T00:00:00.000Z"
ATM
NoteATM
Mtime"2025-08-21T00:00:00.000Z"
ATR
NoteATR
Mtime"2025-08-21T00:00:00.000Z"
BAK (BAK1)
NoteBAK (BAK1)
Mtime"2025-08-21T00:00:00.000Z"
BAX
NoteBAX
Mtime"2025-08-21T00:00:00.000Z"
BCL‑2
NoteBCL‑2
Mtime"2025-08-21T00:00:00.000Z"
BCL‑XL (BCL2L1)
NoteBCL‑XL (BCL2L1)
Mtime"2025-08-21T00:00:00.000Z"
beta-catenin (CTNNB1)
Notebeta-catenin (CTNNB1)
Mtime"2025-08-21T00:00:00.000Z"
BRAF (BRAF)
NoteBRAF (BRAF)
Mtime"2025-08-21T00:00:00.000Z"
Caspase-3 (CASP3)
NoteCaspase-3 (CASP3)
Mtime"2025-08-21T00:00:00.000Z"
CTLA-4 (CTLA4)
NoteCTLA-4 (CTLA4)
Mtime"2025-08-21T00:00:00.000Z"
E2F1 (E2F1)
NoteE2F1 (E2F1)
Mtime"2025-08-21T00:00:00.000Z"
EGF (EGF)
NoteEGF (EGF)
Mtime"2025-08-21T00:00:00.000Z"
EGFR (ERBB1)
NoteEGFR (ERBB1)
Mtime"2025-08-21T00:00:00.000Z"
FAS (CD95)
NoteFAS (CD95)
Mtime"2025-08-21T00:00:00.000Z"
Fibrinogen alpha chain (FGA)
NoteFibrinogen alpha chain (FGA)
Mtime"2025-08-21T00:00:00.000Z"
Flower (Drosophila)
NoteFlower (Drosophila)
Mtime"2025-08-21T00:00:00.000Z"
HLA-A (HLA-A)
NoteHLA-A (HLA-A)
Mtime"2025-08-21T00:00:00.000Z"
IGF-1
NoteIGF-1
Mtime"2025-08-21T00:00:00.000Z"
IL-10
NoteIL-10
Mtime"2025-08-21T00:00:00.000Z"
IL-6
NoteIL-6
Mtime"2025-08-21T00:00:00.000Z"
IL-8 (CXCL8)
NoteIL-8 (CXCL8)
Mtime"2025-08-21T00:00:00.000Z"
Insulin
NoteInsulin
Mtime"2025-08-21T00:00:00.000Z"
KRAS (KRAS)
NoteKRAS (KRAS)
Mtime"2025-08-21T00:00:00.000Z"
MAP2K1 (MEK1)
NoteMAP2K1 (MEK1)
Mtime"2025-08-21T00:00:00.000Z"
MCL-1
NoteMCL-1
Mtime"2025-08-21T00:00:00.000Z"
MDM2
NoteMDM2
Mtime"2025-08-21T00:00:00.000Z"
MMP9 (MMP9)
NoteMMP9 (MMP9)
Mtime"2025-08-21T00:00:00.000Z"
MYC
NoteMYC
Mtime"2025-08-21T00:00:00.000Z"
NOTCH1 (NOTCH1)
NoteNOTCH1 (NOTCH1)
Mtime"2025-08-21T00:00:00.000Z"
p16^INK4a (CDKN2A)
Notep16^INK4a (CDKN2A)
Mtime"2025-08-21T00:00:00.000Z"
p21^CIP1 (CDKN1A)
Notep21^CIP1 (CDKN1A)
Mtime"2025-08-21T00:00:00.000Z"
p53 (TP53)
Notep53 (TP53)
Mtime"2025-08-21T00:00:00.000Z"
PD-1 (PDCD1)
NotePD-1 (PDCD1)
Mtime"2025-08-21T00:00:00.000Z"
PD-L1 (CD274)
NotePD-L1 (CD274)
Mtime"2025-08-21T00:00:00.000Z"
PIK3CA (PIK3CA)
NotePIK3CA (PIK3CA)
Mtime"2025-08-21T00:00:00.000Z"
Rb (RB1)
NoteRb (RB1)
Mtime"2025-08-21T00:00:00.000Z"
Sonic hedgehog (SHH)
NoteSonic hedgehog (SHH)
Mtime"2025-08-21T00:00:00.000Z"
TAZ (WWTR1)
NoteTAZ (WWTR1)
Mtime"2025-08-21T00:00:00.000Z"
Telomerase (TERT)
NoteTelomerase (TERT)
Mtime"2025-08-21T00:00:00.000Z"
TGF-beta 1 (TGFB1)
NoteTGF-beta 1 (TGFB1)
Mtime"2025-08-21T00:00:00.000Z"
TNF (TNF)
NoteTNF (TNF)
Mtime"2025-08-21T00:00:00.000Z"
VEGF (VEGFA)
NoteVEGF (VEGFA)
Mtime"2025-08-21T00:00:00.000Z"
WNT3A (WNT3A)
NoteWNT3A (WNT3A)
Mtime"2025-08-21T00:00:00.000Z"
YAP (YAP1)
NoteYAP (YAP1)
Mtime"2025-08-21T00:00:00.000Z"
DNMT1
NoteDNMT1
Mtime"2025-10-05T00:00:00.000Z"
JAK2
NoteJAK2
Mtime"2025-10-05T00:00:00.000Z"
LMNA
NoteLMNA
Mtime"2025-10-05T00:00:00.000Z"
OGG1
NoteOGG1
Mtime"2025-10-05T00:00:00.000Z"
QSOX1
NoteQSOX1
Mtime"2025-10-05T00:00:00.000Z"
UBE3A
NoteUBE3A
Mtime"2025-10-05T00:00:00.000Z"
XIAP
NoteXIAP
Mtime"2025-10-05T00:00:00.000Z"
ZEB1
NoteZEB1
Mtime"2025-10-05T00:00:00.000Z"
Armitage–Doll model
NoteArmitage–Doll model
Mtime"2025-11-09T00:00:00.000Z"
Tomasetti–Vogelstein model
NoteTomasetti–Vogelstein model
Mtime"2025-11-09T00:00:00.000Z"
Incentive design for animal lifespan prizes
NoteIncentive design for animal lifespan prizes
Mtime"2025-11-02T00:00:00.000Z"
When to not cure aging
NoteWhen to not cure aging
Mtime"2026-03-29T00:00:00.000Z"
Vigilance glossary
NoteVigilance glossary
Mtime"2025-08-24T00:00:00.000Z"
One-Hit Cancer
NoteOne-Hit Cancer
Mtime"2025-08-10T00:00:00.000Z"
Appendix: Telomere Dynamics, Cancer Suppression, and Evolutionary Insights
NoteAppendix: Telomere Dynamics, Cancer Suppression, and Evolutionary Insights
Mtime"2025-08-10T00:00:00.000Z"
Aging is a disease
NoteAging is a disease
Mtime"2025-08-10T00:00:00.000Z"
Aging research is different from most research
NoteAging research is different from most research
Mtime"2025-08-10T00:00:00.000Z"
Has lifespan extension research plateaued
NoteHas lifespan extension research plateaued
Mtime"2025-08-10T00:00:00.000Z"
Long telomeres extend lifespan
NoteLong telomeres extend lifespan
Mtime"2025-08-10T00:00:00.000Z"
Loyalists, drifters, defectors
NoteLoyalists, drifters, defectors
Mtime"2025-08-10T00:00:00.000Z"
Mutation accumulation misconception
NoteMutation accumulation misconception
Mtime"2025-08-10T00:00:00.000Z"
So you want to be a transmissible tumor
NoteSo you want to be a transmissible tumor
Mtime"2025-08-10T00:00:00.000Z"
The parable of the thermometer
NoteThe parable of the thermometer
Mtime"2025-08-10T00:00:00.000Z"
The Price of Not Being Cancer
NoteThe Price of Not Being Cancer
Mtime"2025-08-10T00:00:00.000Z"
Two types of longevity interventions
NoteTwo types of longevity interventions
Mtime"2025-08-10T00:00:00.000Z"
Vibes are principal components
NoteVibes are principal components
Mtime"2025-08-10T00:00:00.000Z"
Atavistic Theory of Cancer
NoteAtavistic Theory of Cancer
Mtime"2025-08-10T00:00:00.000Z"
Self-Fertilization
NoteSelf-Fertilization
Mtime"2025-08-10T00:00:00.000Z"
Antagonistic Pleiotropy Theory
NoteAntagonistic Pleiotropy Theory
Mtime"2025-08-10T00:00:00.000Z"
Cellular Senescence
NoteCellular Senescence
Mtime"2025-08-10T00:00:00.000Z"
CTVT - Canine Transmissible Venereal Tumor
NoteCTVT - Canine Transmissible Venereal Tumor
Mtime"2025-08-10T00:00:00.000Z"
Death Pact
NoteDeath Pact
Mtime"2025-08-10T00:00:00.000Z"
Defensive Degeneration Theory
NoteDefensive Degeneration Theory
Mtime"2025-08-10T00:00:00.000Z"
Devil Facial Tumor Disease (DFTD)
NoteDevil Facial Tumor Disease (DFTD)
Mtime"2025-08-10T00:00:00.000Z"
Disposable Soma Theory
NoteDisposable Soma Theory
Mtime"2025-08-10T00:00:00.000Z"
HeLa Cells
NoteHeLa Cells
Mtime"2025-08-10T00:00:00.000Z"
Immune Surveillance
NoteImmune Surveillance
Mtime"2025-08-10T00:00:00.000Z"
How malignant cells evade host coordination systems
NoteHow malignant cells evade host coordination systems
Mtime"2025-08-10T00:00:00.000Z"
Principal-Agent Problem
NotePrincipal-Agent Problem
Mtime"2025-08-10T00:00:00.000Z"
Replicative Credit
NoteReplicative Credit
Mtime"2025-08-10T00:00:00.000Z"
SCANDAL Hypothesis
NoteSCANDAL Hypothesis
Mtime"2025-08-10T00:00:00.000Z"
Selection Shadow Theory
NoteSelection Shadow Theory
Mtime"2025-08-10T00:00:00.000Z"
Telomeres
NoteTelomeres
Mtime"2025-08-10T00:00:00.000Z"
Tumor Suppressor Theory of Aging
NoteTumor Suppressor Theory of Aging
Mtime"2025-08-10T00:00:00.000Z"
Weismann Barrier
NoteWeismann Barrier
Mtime"2025-08-10T00:00:00.000Z"
Lewontin's conditions
NoteLewontin's conditions
Mtime"2025-09-20T00:00:00.000Z"
De-Darwinization
NoteDe-Darwinization
Mtime"2025-09-20T00:00:00.000Z"
ctvt_cancer_line
Notectvt_cancer_line
Mtime"2025-10-04T00:00:00.000Z"
Pathway macrostates
NotePathway macrostates
Mtime"2026-05-02T00:00:00.000Z"
Why does DNA Damage Response damage DNA
NoteWhy does DNA Damage Response damage DNA
Mtime"2026-05-02T00:00:00.000Z"
Repairman's paradox trips up engineers in biology
NoteRepairman's paradox trips up engineers in biology
Mtime"2026-06-13T00:00:00.000Z"
Submarine analogy
NoteSubmarine analogy
Mtime"2025-12-06T00:00:00.000Z"
Criticism of Dwarkesh Podcast - Jacob Kimmel Interview
NoteCriticism of Dwarkesh Podcast - Jacob Kimmel Interview
Mtime"2025-08-23T00:00:00.000Z"
Biologist learns control theory
NoteBiologist learns control theory
Mtime"2026-04-11T00:00:00.000Z"
What is an agent
NoteWhat is an agent
Mtime"2025-10-20T00:00:00.000Z"
why dont biologists use openreview
Notewhy dont biologists use openreview
Mtime"2026-05-11T00:00:00.000Z"
Types of cell senescence
NoteTypes of cell senescence
Mtime"2026-05-04T00:00:00.000Z"
Evolutionary Transitions in Individuality: much more than you wanted to know
NoteEvolutionary Transitions in Individuality: much more than you wanted to know
Mtime"2026-03-02T00:00:00.000Z"
Labs
NoteLabs
Mtime"2026-06-08T00:00:00.000Z"
Types of explanations in biology
NoteTypes of explanations in biology
Mtime"2026-01-12T00:00:00.000Z"
Why would cancer cure Alzheimer's?
NoteWhy would cancer cure Alzheimer's?
Mtime"2026-02-09T00:00:00.000Z"
The first sacrifice
NoteThe first sacrifice
Mtime"2026-02-02T00:00:00.000Z"
10 intuitions on tissue architecture
Note10 intuitions on tissue architecture
Mtime"2025-12-22T00:00:00.000Z"
Evolution Simulation Demo
NoteEvolution Simulation Demo
Mtime"2025-08-11T00:00:00.000Z"
Why doesn't liver age faster?
NoteWhy doesn't liver age faster?
Mtime"2026-04-27T00:00:00.000Z"
Indeterminate growth
NoteIndeterminate growth
Mtime"2025-09-05T00:00:00.000Z"
Dump note
NoteDump note
Mtime"2025-10-10T00:00:00.000Z"
Somatic Engineering Manifesto
NoteSomatic Engineering Manifesto
Mtime"2025-11-07T00:00:00.000Z"
Defensive sabotage is not friendly fire
NoteDefensive sabotage is not friendly fire
Mtime"2026-03-20T00:00:00.000Z"
Repurposed for altruism
NoteRepurposed for altruism
Mtime"2026-03-06T00:00:00.000Z"
No data found.
No data found.