Showing 147 of 147 entries
StageNoteUpdatedStatus
draftMeasuring somatic mosaicism and genomic instability124d ago
draftMitosis vetoes131d ago
draftWhy would fish cells die when fish dies?145d ago
draftHow come theres 1 smell per neuron201d ago
draftEutely334d ago
draftTypes of scientific explanations103d ago
draftTaxonomy of AI footguns for non-coders321d ago
draftAKT1321d ago
draftFOXO3 (FOXO3)321d ago
draftGAPDH321d ago
draftMTOR (MTOR)321d ago
draftNFE2L2 (NRF2)321d ago
draftPRKAA1 (AMPKα1)321d ago
draftSIRT1 (SIRT1)321d ago
draftWould pharma whistleblower bounties help or hurt the war on aging?62d ago
draftClonal governance69d ago
draftMemes111d ago
draftImmortality has a PR problem118d ago
draftTutorial: Iconoplasm API for third-party developers27d ago
draftMultipolar traps in multicellularity146d ago
draftDunking on medawar selection shadow160d ago
draftTypes of tumor suppressor genes223d ago
draftResearch Gaps — Cnidarian Longevity & Rejuvenation335d agodraft
draftTrivia116d ago
draftCausal inference frameworks in biology25d ago
draftAKT2 (AKT2)333d ago
draftAPAF1333d ago
draftARF (p14^ARF)333d ago
draftATM333d ago
draftATR333d ago
draftBAK (BAK1)333d ago
draftBAX333d ago
draftBCL‑2333d ago
draftBCL‑XL (BCL2L1)333d ago
draftbeta-catenin (CTNNB1)333d ago
draftBRAF (BRAF)333d ago
draftCaspase-3 (CASP3)333d ago
draftCTLA-4 (CTLA4)333d ago
draftE2F1 (E2F1)333d ago
draftEGF (EGF)333d ago
draftEGFR (ERBB1)333d ago
draftFAS (CD95)333d ago
draftFibrinogen alpha chain (FGA)333d ago
draftFlower (Drosophila)333d agodraft
draftHLA-A (HLA-A)333d ago
draftIGF-1333d agodraft
draftIL-10333d agodraft
draftIL-6333d agodraft
draftIL-8 (CXCL8)333d agodraft
draftInsulin333d agodraft
draftKRAS (KRAS)333d ago
draftMAP2K1 (MEK1)333d ago
draftMCL-1333d agodraft
draftMDM2333d agodraft
draftMMP9 (MMP9)333d ago
draftMYC333d agodraft
draftNOTCH1 (NOTCH1)333d ago
draftp16^INK4a (CDKN2A)333d agodraft
draftp21^CIP1 (CDKN1A)333d agodraft
draftp53 (TP53)333d agodraft
draftPD-1 (PDCD1)333d agodraft
draftPD-L1 (CD274)333d agodraft
draftPIK3CA (PIK3CA)333d ago
draftRb (RB1)333d agodraft
draftSonic hedgehog (SHH)333d ago
draftTAZ (WWTR1)333d agodraft
draftTelomerase (TERT)333d agodraft
draftTGF-beta 1 (TGFB1)333d ago
draftTNF (TNF)333d ago
draftVEGF (VEGFA)333d agodraft
draftWNT3A (WNT3A)333d ago
draftYAP (YAP1)333d agodraft
draftDNMT1288d ago
draftJAK2288d ago
draftLMNA288d ago
draftOGG1288d ago
draftQSOX1288d ago
draftUBE3A288d ago
draftXIAP288d ago
draftZEB1288d ago
draftArmitage–Doll model253d ago
draftTomasetti–Vogelstein model253d ago
draftIncentive design for animal lifespan prizes260d ago
draftWhen to not cure aging113d ago
draftGoldbeter–Koshland module29d ago
draftHopf bifurcation29d ago
draftHuang-Ferrell model29d ago
draftNovak–Tyson model29d ago
draftRecommendations323d ago
draftVigilance glossary330d ago
draftOne-Hit Cancer344d ago
draftAppendix: Telomere Dynamics, Cancer Suppression, and Evolutionary Insights344d ago
draftAging is a disease344d ago
draftAging research is different from most research344d ago
draftHas lifespan extension research plateaued344d ago
draftLong telomeres extend lifespan344d ago
draftLoyalists, drifters, defectors344d ago
draftMutation accumulation misconception344d ago
draftSo you want to be a transmissible tumor344d ago
draftThe parable of the thermometer344d ago
draftThe Price of Not Being Cancer344d ago
draftTwo types of longevity interventions344d ago
draftVibes are principal components344d ago
draftAtavistic Theory of Cancer344d ago
draftSelf-Fertilization344d ago
draftAntagonistic Pleiotropy Theory344d ago
draftCellular Senescence344d ago
draftCTVT - Canine Transmissible Venereal Tumor344d ago
draftDeath Pact344d ago
draftDefensive Degeneration Theory344d ago
draftDevil Facial Tumor Disease (DFTD)344d ago
draftDisposable Soma Theory344d ago
draftHeLa Cells344d ago
draftImmune Surveillance344d ago
draftHow malignant cells evade host coordination systems344d ago
draftPrincipal-Agent Problem344d ago
draftReplicative Credit344d ago
draftSCANDAL Hypothesis344d ago
draftSelection Shadow Theory344d ago
draftTelomeres344d ago
draftTumor Suppressor Theory of Aging344d ago
draftWeismann Barrier344d ago
draftLewontin's conditions303d ago
draftDe-Darwinization303d ago
draftctvt_cancer_line289d ago
draftPathway macrostates79d ago
draftWhy does DNA Damage Response damage DNA79d ago
draftHow sprinkler fallacy trips up engineers in biology37d ago
draftSubmarine analogy226d ago
draftCriticism of Dwarkesh Podcast - Jacob Kimmel Interview331d ago
draftBiologist learns control theory100d ago
draftWhat is an agent273d ago
draftwhy dont biologists use openreview70d ago
draftTypes of cell senescence77d ago
draftEvolutionary Transitions in Individuality: much more than you wanted to know140d ago
draftLabs42d ago
draftTypes of explanations in biology189d ago
draftWhy would cancer cure Alzheimer's?161d ago
draftThe first sacrifice168d ago
draft10 intuitions on tissue architecture210d ago
draftEvolution Simulation Demo343d ago
draftWhy doesn't liver age faster?84d ago
draftIndeterminate growth318d ago
draftSomatic Engineering Manifesto255d ago
draftDefensive sabotage is not friendly fire122d ago
draftRepurposed for altruism136d ago
draftFour eras of aging research24d ago
Showing 147 of 147 entries
Measuring somatic mosaicism and genomic instability
NoteMeasuring somatic mosaicism and genomic instability
Mtime"2026-03-18T00:00:00.000Z"
Mitosis vetoes
NoteMitosis vetoes
Mtime"2026-03-11T00:00:00.000Z"
Why would fish cells die when fish dies?
NoteWhy would fish cells die when fish dies?
Mtime"2026-02-25T00:00:00.000Z"
How come theres 1 smell per neuron
NoteHow come theres 1 smell per neuron
Mtime"2025-12-31T00:00:00.000Z"
Eutely
NoteEutely
Mtime"2025-08-20T00:00:00.000Z"
Types of scientific explanations
NoteTypes of scientific explanations
Mtime"2026-04-08T00:00:00.000Z"
Taxonomy of AI footguns for non-coders
NoteTaxonomy of AI footguns for non-coders
Mtime"2025-09-02T00:00:00.000Z"
AKT1
NoteAKT1
Mtime"2025-09-02T00:00:00.000Z"
FOXO3 (FOXO3)
NoteFOXO3 (FOXO3)
Mtime"2025-09-02T00:00:00.000Z"
GAPDH
NoteGAPDH
Mtime"2025-09-02T00:00:00.000Z"
MTOR (MTOR)
NoteMTOR (MTOR)
Mtime"2025-09-02T00:00:00.000Z"
NFE2L2 (NRF2)
NoteNFE2L2 (NRF2)
Mtime"2025-09-02T00:00:00.000Z"
PRKAA1 (AMPKα1)
NotePRKAA1 (AMPKα1)
Mtime"2025-09-02T00:00:00.000Z"
SIRT1 (SIRT1)
NoteSIRT1 (SIRT1)
Mtime"2025-09-02T00:00:00.000Z"
Would pharma whistleblower bounties help or hurt the war on aging?
NoteWould pharma whistleblower bounties help or hurt the war on aging?
Mtime"2026-05-19T00:00:00.000Z"
Clonal governance
NoteClonal governance
Mtime"2026-05-12T00:00:00.000Z"
Memes
NoteMemes
Mtime"2026-03-31T00:00:00.000Z"
Immortality has a PR problem
NoteImmortality has a PR problem
Mtime"2026-03-24T00:00:00.000Z"
Tutorial: Iconoplasm API for third-party developers
NoteTutorial: Iconoplasm API for third-party developers
Mtime"2026-06-23T00:00:00.000Z"
Multipolar traps in multicellularity
NoteMultipolar traps in multicellularity
Mtime"2026-02-24T00:00:00.000Z"
Dunking on medawar selection shadow
NoteDunking on medawar selection shadow
Mtime"2026-02-10T00:00:00.000Z"
Types of tumor suppressor genes
NoteTypes of tumor suppressor genes
Mtime"2025-12-09T00:00:00.000Z"
Research Gaps — Cnidarian Longevity & Rejuvenation
NoteResearch Gaps — Cnidarian Longevity & Rejuvenation
Mtime"2025-08-19T00:00:00.000Z"
Trivia
NoteTrivia
Mtime"2026-03-26T00:00:00.000Z"
Causal inference frameworks in biology
NoteCausal inference frameworks in biology
Mtime"2026-06-25T00:00:00.000Z"
AKT2 (AKT2)
NoteAKT2 (AKT2)
Mtime"2025-08-21T00:00:00.000Z"
APAF1
NoteAPAF1
Mtime"2025-08-21T00:00:00.000Z"
ARF (p14^ARF)
NoteARF (p14^ARF)
Mtime"2025-08-21T00:00:00.000Z"
ATM
NoteATM
Mtime"2025-08-21T00:00:00.000Z"
ATR
NoteATR
Mtime"2025-08-21T00:00:00.000Z"
BAK (BAK1)
NoteBAK (BAK1)
Mtime"2025-08-21T00:00:00.000Z"
BAX
NoteBAX
Mtime"2025-08-21T00:00:00.000Z"
BCL‑2
NoteBCL‑2
Mtime"2025-08-21T00:00:00.000Z"
BCL‑XL (BCL2L1)
NoteBCL‑XL (BCL2L1)
Mtime"2025-08-21T00:00:00.000Z"
beta-catenin (CTNNB1)
Notebeta-catenin (CTNNB1)
Mtime"2025-08-21T00:00:00.000Z"
BRAF (BRAF)
NoteBRAF (BRAF)
Mtime"2025-08-21T00:00:00.000Z"
Caspase-3 (CASP3)
NoteCaspase-3 (CASP3)
Mtime"2025-08-21T00:00:00.000Z"
CTLA-4 (CTLA4)
NoteCTLA-4 (CTLA4)
Mtime"2025-08-21T00:00:00.000Z"
E2F1 (E2F1)
NoteE2F1 (E2F1)
Mtime"2025-08-21T00:00:00.000Z"
EGF (EGF)
NoteEGF (EGF)
Mtime"2025-08-21T00:00:00.000Z"
EGFR (ERBB1)
NoteEGFR (ERBB1)
Mtime"2025-08-21T00:00:00.000Z"
FAS (CD95)
NoteFAS (CD95)
Mtime"2025-08-21T00:00:00.000Z"
Fibrinogen alpha chain (FGA)
NoteFibrinogen alpha chain (FGA)
Mtime"2025-08-21T00:00:00.000Z"
Flower (Drosophila)
NoteFlower (Drosophila)
Mtime"2025-08-21T00:00:00.000Z"
HLA-A (HLA-A)
NoteHLA-A (HLA-A)
Mtime"2025-08-21T00:00:00.000Z"
IGF-1
NoteIGF-1
Mtime"2025-08-21T00:00:00.000Z"
IL-10
NoteIL-10
Mtime"2025-08-21T00:00:00.000Z"
IL-6
NoteIL-6
Mtime"2025-08-21T00:00:00.000Z"
IL-8 (CXCL8)
NoteIL-8 (CXCL8)
Mtime"2025-08-21T00:00:00.000Z"
Insulin
NoteInsulin
Mtime"2025-08-21T00:00:00.000Z"
KRAS (KRAS)
NoteKRAS (KRAS)
Mtime"2025-08-21T00:00:00.000Z"
MAP2K1 (MEK1)
NoteMAP2K1 (MEK1)
Mtime"2025-08-21T00:00:00.000Z"
MCL-1
NoteMCL-1
Mtime"2025-08-21T00:00:00.000Z"
MDM2
NoteMDM2
Mtime"2025-08-21T00:00:00.000Z"
MMP9 (MMP9)
NoteMMP9 (MMP9)
Mtime"2025-08-21T00:00:00.000Z"
MYC
NoteMYC
Mtime"2025-08-21T00:00:00.000Z"
NOTCH1 (NOTCH1)
NoteNOTCH1 (NOTCH1)
Mtime"2025-08-21T00:00:00.000Z"
p16^INK4a (CDKN2A)
Notep16^INK4a (CDKN2A)
Mtime"2025-08-21T00:00:00.000Z"
p21^CIP1 (CDKN1A)
Notep21^CIP1 (CDKN1A)
Mtime"2025-08-21T00:00:00.000Z"
p53 (TP53)
Notep53 (TP53)
Mtime"2025-08-21T00:00:00.000Z"
PD-1 (PDCD1)
NotePD-1 (PDCD1)
Mtime"2025-08-21T00:00:00.000Z"
PD-L1 (CD274)
NotePD-L1 (CD274)
Mtime"2025-08-21T00:00:00.000Z"
PIK3CA (PIK3CA)
NotePIK3CA (PIK3CA)
Mtime"2025-08-21T00:00:00.000Z"
Rb (RB1)
NoteRb (RB1)
Mtime"2025-08-21T00:00:00.000Z"
Sonic hedgehog (SHH)
NoteSonic hedgehog (SHH)
Mtime"2025-08-21T00:00:00.000Z"
TAZ (WWTR1)
NoteTAZ (WWTR1)
Mtime"2025-08-21T00:00:00.000Z"
Telomerase (TERT)
NoteTelomerase (TERT)
Mtime"2025-08-21T00:00:00.000Z"
TGF-beta 1 (TGFB1)
NoteTGF-beta 1 (TGFB1)
Mtime"2025-08-21T00:00:00.000Z"
TNF (TNF)
NoteTNF (TNF)
Mtime"2025-08-21T00:00:00.000Z"
VEGF (VEGFA)
NoteVEGF (VEGFA)
Mtime"2025-08-21T00:00:00.000Z"
WNT3A (WNT3A)
NoteWNT3A (WNT3A)
Mtime"2025-08-21T00:00:00.000Z"
YAP (YAP1)
NoteYAP (YAP1)
Mtime"2025-08-21T00:00:00.000Z"
DNMT1
NoteDNMT1
Mtime"2025-10-05T00:00:00.000Z"
JAK2
NoteJAK2
Mtime"2025-10-05T00:00:00.000Z"
LMNA
NoteLMNA
Mtime"2025-10-05T00:00:00.000Z"
OGG1
NoteOGG1
Mtime"2025-10-05T00:00:00.000Z"
QSOX1
NoteQSOX1
Mtime"2025-10-05T00:00:00.000Z"
UBE3A
NoteUBE3A
Mtime"2025-10-05T00:00:00.000Z"
XIAP
NoteXIAP
Mtime"2025-10-05T00:00:00.000Z"
ZEB1
NoteZEB1
Mtime"2025-10-05T00:00:00.000Z"
Armitage–Doll model
NoteArmitage–Doll model
Mtime"2025-11-09T00:00:00.000Z"
Tomasetti–Vogelstein model
NoteTomasetti–Vogelstein model
Mtime"2025-11-09T00:00:00.000Z"
Incentive design for animal lifespan prizes
NoteIncentive design for animal lifespan prizes
Mtime"2025-11-02T00:00:00.000Z"
When to not cure aging
NoteWhen to not cure aging
Mtime"2026-03-29T00:00:00.000Z"
Goldbeter–Koshland module
NoteGoldbeter–Koshland module
Mtime"2026-06-21T00:00:00.000Z"
Hopf bifurcation
NoteHopf bifurcation
Mtime"2026-06-21T00:00:00.000Z"
Huang-Ferrell model
NoteHuang-Ferrell model
Mtime"2026-06-21T00:00:00.000Z"
Novak–Tyson model
NoteNovak–Tyson model
Mtime"2026-06-21T00:00:00.000Z"
Recommendations
NoteRecommendations
Mtime"2025-08-31T00:00:00.000Z"
Vigilance glossary
NoteVigilance glossary
Mtime"2025-08-24T00:00:00.000Z"
One-Hit Cancer
NoteOne-Hit Cancer
Mtime"2025-08-10T00:00:00.000Z"
Appendix: Telomere Dynamics, Cancer Suppression, and Evolutionary Insights
NoteAppendix: Telomere Dynamics, Cancer Suppression, and Evolutionary Insights
Mtime"2025-08-10T00:00:00.000Z"
Aging is a disease
NoteAging is a disease
Mtime"2025-08-10T00:00:00.000Z"
Aging research is different from most research
NoteAging research is different from most research
Mtime"2025-08-10T00:00:00.000Z"
Has lifespan extension research plateaued
NoteHas lifespan extension research plateaued
Mtime"2025-08-10T00:00:00.000Z"
Long telomeres extend lifespan
NoteLong telomeres extend lifespan
Mtime"2025-08-10T00:00:00.000Z"
Loyalists, drifters, defectors
NoteLoyalists, drifters, defectors
Mtime"2025-08-10T00:00:00.000Z"
Mutation accumulation misconception
NoteMutation accumulation misconception
Mtime"2025-08-10T00:00:00.000Z"
So you want to be a transmissible tumor
NoteSo you want to be a transmissible tumor
Mtime"2025-08-10T00:00:00.000Z"
The parable of the thermometer
NoteThe parable of the thermometer
Mtime"2025-08-10T00:00:00.000Z"
The Price of Not Being Cancer
NoteThe Price of Not Being Cancer
Mtime"2025-08-10T00:00:00.000Z"
Two types of longevity interventions
NoteTwo types of longevity interventions
Mtime"2025-08-10T00:00:00.000Z"
Vibes are principal components
NoteVibes are principal components
Mtime"2025-08-10T00:00:00.000Z"
Atavistic Theory of Cancer
NoteAtavistic Theory of Cancer
Mtime"2025-08-10T00:00:00.000Z"
Self-Fertilization
NoteSelf-Fertilization
Mtime"2025-08-10T00:00:00.000Z"
Antagonistic Pleiotropy Theory
NoteAntagonistic Pleiotropy Theory
Mtime"2025-08-10T00:00:00.000Z"
Cellular Senescence
NoteCellular Senescence
Mtime"2025-08-10T00:00:00.000Z"
CTVT - Canine Transmissible Venereal Tumor
NoteCTVT - Canine Transmissible Venereal Tumor
Mtime"2025-08-10T00:00:00.000Z"
Death Pact
NoteDeath Pact
Mtime"2025-08-10T00:00:00.000Z"
Defensive Degeneration Theory
NoteDefensive Degeneration Theory
Mtime"2025-08-10T00:00:00.000Z"
Devil Facial Tumor Disease (DFTD)
NoteDevil Facial Tumor Disease (DFTD)
Mtime"2025-08-10T00:00:00.000Z"
Disposable Soma Theory
NoteDisposable Soma Theory
Mtime"2025-08-10T00:00:00.000Z"
HeLa Cells
NoteHeLa Cells
Mtime"2025-08-10T00:00:00.000Z"
Immune Surveillance
NoteImmune Surveillance
Mtime"2025-08-10T00:00:00.000Z"
How malignant cells evade host coordination systems
NoteHow malignant cells evade host coordination systems
Mtime"2025-08-10T00:00:00.000Z"
Principal-Agent Problem
NotePrincipal-Agent Problem
Mtime"2025-08-10T00:00:00.000Z"
Replicative Credit
NoteReplicative Credit
Mtime"2025-08-10T00:00:00.000Z"
SCANDAL Hypothesis
NoteSCANDAL Hypothesis
Mtime"2025-08-10T00:00:00.000Z"
Selection Shadow Theory
NoteSelection Shadow Theory
Mtime"2025-08-10T00:00:00.000Z"
Telomeres
NoteTelomeres
Mtime"2025-08-10T00:00:00.000Z"
Tumor Suppressor Theory of Aging
NoteTumor Suppressor Theory of Aging
Mtime"2025-08-10T00:00:00.000Z"
Weismann Barrier
NoteWeismann Barrier
Mtime"2025-08-10T00:00:00.000Z"
Lewontin's conditions
NoteLewontin's conditions
Mtime"2025-09-20T00:00:00.000Z"
De-Darwinization
NoteDe-Darwinization
Mtime"2025-09-20T00:00:00.000Z"
ctvt_cancer_line
Notectvt_cancer_line
Mtime"2025-10-04T00:00:00.000Z"
Pathway macrostates
NotePathway macrostates
Mtime"2026-05-02T00:00:00.000Z"
Why does DNA Damage Response damage DNA
NoteWhy does DNA Damage Response damage DNA
Mtime"2026-05-02T00:00:00.000Z"
How sprinkler fallacy trips up engineers in biology
NoteHow sprinkler fallacy trips up engineers in biology
Mtime"2026-06-13T00:00:00.000Z"
Submarine analogy
NoteSubmarine analogy
Mtime"2025-12-06T00:00:00.000Z"
Criticism of Dwarkesh Podcast - Jacob Kimmel Interview
NoteCriticism of Dwarkesh Podcast - Jacob Kimmel Interview
Mtime"2025-08-23T00:00:00.000Z"
Biologist learns control theory
NoteBiologist learns control theory
Mtime"2026-04-11T00:00:00.000Z"
What is an agent
NoteWhat is an agent
Mtime"2025-10-20T00:00:00.000Z"
why dont biologists use openreview
Notewhy dont biologists use openreview
Mtime"2026-05-11T00:00:00.000Z"
Types of cell senescence
NoteTypes of cell senescence
Mtime"2026-05-04T00:00:00.000Z"
Evolutionary Transitions in Individuality: much more than you wanted to know
NoteEvolutionary Transitions in Individuality: much more than you wanted to know
Mtime"2026-03-02T00:00:00.000Z"
Labs
NoteLabs
Mtime"2026-06-08T00:00:00.000Z"
Types of explanations in biology
NoteTypes of explanations in biology
Mtime"2026-01-12T00:00:00.000Z"
Why would cancer cure Alzheimer's?
NoteWhy would cancer cure Alzheimer's?
Mtime"2026-02-09T00:00:00.000Z"
The first sacrifice
NoteThe first sacrifice
Mtime"2026-02-02T00:00:00.000Z"
10 intuitions on tissue architecture
Note10 intuitions on tissue architecture
Mtime"2025-12-22T00:00:00.000Z"
Evolution Simulation Demo
NoteEvolution Simulation Demo
Mtime"2025-08-11T00:00:00.000Z"
Why doesn't liver age faster?
NoteWhy doesn't liver age faster?
Mtime"2026-04-27T00:00:00.000Z"
Indeterminate growth
NoteIndeterminate growth
Mtime"2025-09-05T00:00:00.000Z"
Somatic Engineering Manifesto
NoteSomatic Engineering Manifesto
Mtime"2025-11-07T00:00:00.000Z"
Defensive sabotage is not friendly fire
NoteDefensive sabotage is not friendly fire
Mtime"2026-03-20T00:00:00.000Z"
Repurposed for altruism
NoteRepurposed for altruism
Mtime"2026-03-06T00:00:00.000Z"
Four eras of aging research
NoteFour eras of aging research
Mtime"2026-06-26T00:00:00.000Z"
No data found.
No data found.